ESPE Yearbook of Paediatric Endocrinology

Preface: This year, many new mechanisms and new concepts have been described in neuroendocrinology. Investigating physiology or pathogenic mechanisms but also developing biological markers of neuroendocrine dysfunctions in humans is very challenging. Several strategies are needed: dosage of neuropeptides in the cerebrospinal fluid, genome-wide association studies in very large population studies, classical genetic investigation in mice but also studies on invertebrates to unde...

This year has been very rich in highly interesting papers in Neuroendocrinology. Some papers reported in this selection described new mechanisms, but also new mouse models to understand or to investigate pediatric endocrinopathies. In these 12 papers, one of them stands out as highly remarkable by the originality of the hypothesis, the quality of the work but also for the perspectives in medicine. This paper by Zhang et al. demonstrates the importance of hypothalamic stem/prog...